![]() For that, HeLa cells were injected into a RAD16-I peptide scaffold containing. Nanoparticles can also be used for controlled release delivery of drugs and growth factors to improve tissue engineering and structural strength. Tissue Engineering Research Laboratory, Department of Bioengineering, IQS. Antioxidant nanoparticles for siRNA delivery to modulate fibrogenesis.The goal is to augment soft tissue regeneration while also restoring load-bearing tissue architecture. We use regional spatial, compositional and mechanical cues to differentially regulate cell fate and phenotypic maintenance. This review will focus on the recent advancement of numerous 3D-based scaffold models for cancer tissue engineering, which will increase the predictive ability of preclinical studies and significantly improve clinical translation. Engineering biomaterials that address the complex tissue damage at the interface of muscle and bone.Generation of cell-free biomaterials to modulate immune system activity via biomechanical, chemical and topographical cues to guide host-driven regeneration and healing. ![]() The goal of this research is improved outcomes for grafting and ECMO (Extracorporeal Membrane Oxygenation) devices. We also use devices that imitate physiological systems in order to understand the impact of flow on endothelial cells when complexed with spatial patterning and mechanical gradients. Engineering cardiovascular tissues, including small-diameter blood vessel grafts that resist the formation of atherosclerotic lesions, developed by changing the inflammatory potential of endothelial cells lining the blood vessels.We use 3D bioprinting and advanced biofabrication techniques to study tissue architecture, cell-to-cell communication and mechanical and transport properties of the tumor environment. Developing dynamic tissue-engineered platforms to model cancer progression starting from its early stages, studying disease progression and developing new ways to detect it earlier.students have been recognized for their work in this area through multiple awards at the national Society for Biomaterials conference. Our goals include healing wounds, controlling blood vessel growth and improving functional tissue regeneration. Developing stimuli-responsive biomaterial scaffolds that respond to externally applied physical cues, allowing precise control of cell signaling and behavior.
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